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Atenolol Tablets In Pakistan
Atenolol Tablets is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used to treat chest pain (angina) and improve survival after a heart attack. Atenolol belongs to a class of drugs known as beta blockers. It works by blocking the action of certain natural chemicals in your body, such as epinephrine, on your heart and blood vessels. This effect lowers heart rate, blood pressure, and strain on the heart.
How to use atenolol?
Take this medication by mouth with or without food as directed by your doctor, usually 1 or 2 times daily.
Apple juice and orange juice can prevent your body from fully absorbing atenolol. It is best to avoid drinking apple/orange juice within 4 hours of taking atenolol, unless otherwise directed by your doctor or pharmacist.
The dosage is based on your medical condition and response to treatment.
Atenolol Tablets Buy In Karachi
Atenolol is a cardioselective beta-blocker, so named because it selectively binds to the β1-adrenergic receptor as an antagonist up to 26 times more than β2 receptors.15 Selective activity at the β1 receptor results in cardioselectivity due to the larger population of this receptor in tissue. cardiac. Some binding to β2 and possibly β3 receptors may still occur at therapeutic doses, but effects mediated by antagonism of these are significantly reduced relative to those of nonselective agents. β1 and β2 receptors are G-coupled, so antagonism of their activation reduces adenylyl cyclase activity and its downstream signaling through cyclic adenosine monophosphate and protein kinase A (PKA).
In cardiomyocytes, PKA is thought to mediate the activation of L-type calcium channels and ryanodine receptors through their phosphorylation.16 L-type calcium channels may provide an initial increase in intracellular calcium and trigger ryanodine receptors release calcium stored in the sarcoplasmic reticulum (SR) and increased contractility.
